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Research Article |

Inflammatory Markers in the Diagnosis of Neonatal Necrotizing Enterocolitis

As a serious gastrointestinal disease in newborns, neonatal necrotizing enterocolitis (NEC) is characterized by an acute onset, rapid progression and high mortality. The pathogenesis of NEC is complex, which makes diagnosis difficult. The diagnostic gold standard of NEC occurs via intestinal biopsy, but this is not feasible for practical clinical applications. Therefore, the diagnosis of NEC at this stage mainly depends on clinical symptoms and abdominal X-ray imaging. However, the clinical symptoms of infants with early NEC are not specific and the characteristic manifestations seen on imaging often only appear during a critical state of NEC, which easily leads to misdiagnosis or the delay of treatment. Thus, finding a reliable diagnostic method to achieve early diagnosis and treatment is necessary to improve prognosis. As a simple and feasible new diagnostic method in the clinic, inflammatory markers have broad application prospects. In this paper, the common inflammatory markers for early diagnosis of NEC are reviewed from the aspects of the molecular mechanism, research status, and feasibility of the clinical application, including serum amyloid A, C-reactive protein, procalcitonin, fecal calprotectin, intestinal fatty acid binding protein, and cytosolic β-glucosidase. Studies have shown that inflammatory markers possess clinical potential for the early diagnosis of NEC, showing more advantages than traditional imaging methods. However, at present, the research is still limited to small sample and single-center research studies, and evidence from large sample sizes, multi-center studies, and multi-inflammatory markers will be needed to support by additional studies in the future.

Neonatal Necrotizing Enterocolitis, Inflammatory Markers, Early Diagnosis, Literature Review

APA Style

Chen, Y., Pan, Y., Fan, Q. (2023). Inflammatory Markers in the Diagnosis of Neonatal Necrotizing Enterocolitis. American Journal of Clinical and Experimental Medicine, 11(5), 86-91.

ACS Style

Chen, Y.; Pan, Y.; Fan, Q. Inflammatory Markers in the Diagnosis of Neonatal Necrotizing Enterocolitis. Am. J. Clin. Exp. Med. 2023, 11(5), 86-91. doi: 10.11648/j.ajcem.20231105.11

AMA Style

Chen Y, Pan Y, Fan Q. Inflammatory Markers in the Diagnosis of Neonatal Necrotizing Enterocolitis. Am J Clin Exp Med. 2023;11(5):86-91. doi: 10.11648/j.ajcem.20231105.11

Copyright © 2023 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License ( which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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