Volume 2, Issue 6, November 2014, Page: 117-122
The Analysis Mutation of the CARD15 Gene Variants in Chronic Periodontitis
Asmawati Amin, Department of Oral Biology, Faculty of Dentistry, Hasanuddin University, Makassar, Indonesia
Bahruddin Thalib, Department, of Prosthodontia, Faculty of Dentistry , Hasanuddin University, Makassar, Indonesia
Mochammad Hatta, Molecular Biology and Immunology Laboratory for Infectious Diseases, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia
Received: Oct. 1, 2014;       Accepted: Oct. 17, 2014;       Published: Oct. 30, 2014
DOI: 10.11648/j.ajcem.20140206.11      View  2290      Downloads  226
Abstract
Purpose of this study was to determine the variant of CARD 15 gene mutations with periodontitis chronic .Identified by using polymerase chain reaction (PCR) and folowed by using restriction fragment length polymorphism analysis (RFLP). CARD 15 gene mutation with chronic periodontitis were found heterozygote mutation and homozygote mutation variants base on statistical analysis there were significant with control group ( p= 0,005) and also was founded genetics variation that changed the composition of C → T nucleotide at codon 802 in exon 4 amino acid, from alanine to valine.
Keywords
CARD 15 Gene, Mutation, Chronic Periodontitis, Heterozygote, Homozygote
To cite this article
Asmawati Amin, Bahruddin Thalib, Mochammad Hatta, The Analysis Mutation of the CARD15 Gene Variants in Chronic Periodontitis, American Journal of Clinical and Experimental Medicine. Vol. 2, No. 6, 2014, pp. 117-122. doi: 10.11648/j.ajcem.20140206.11
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