Volume 2, Issue 6, November 2014, Page: 128-131
Constitutional Pericentric Inversion of Chromosome 9 and Chronic Myeloid Leukemia
Salil Vaniawala, Molecular Cytogenetic Unit, S. N. Gene Laboratory and Research Centre, President Plaza-A , Near RTO circle, Surat-395001, India
Gadhia Pankaj, P. K. Gadhia, Molecular Cytogenetic Unit, S. N. Gene Lab. and Research Centre, Near RTO circle, Surat – 395001. India
Received: Oct. 10, 2014;       Accepted: Nov. 6, 2014;       Published: Nov. 20, 2014
DOI: 10.11648/j.ajcem.20140206.13      View  2458      Downloads  147
Abstract
In the present study, we screened the bone marrow chromosome database entries between March, 2004 and December, 2013 to identify cases with inv(9) along with t(9;22) variations. Our study recorded 2300 cases of confirmed CML (Ph positive), of which only 12 (0.52%) cases had inv(9) and t(9;22). The association between inv(9) and t(9;22) is not fully explored. Therefore more number of cases is required to shed light on its important role, if any, especially in bone-marrow transplantation and drug resistance.
Keywords
Pericentric Inv (9), CML, t(9; 22), Bone-Marrow
To cite this article
Salil Vaniawala, Gadhia Pankaj, Constitutional Pericentric Inversion of Chromosome 9 and Chronic Myeloid Leukemia, American Journal of Clinical and Experimental Medicine. Vol. 2, No. 6, 2014, pp. 128-131. doi: 10.11648/j.ajcem.20140206.13
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