Volume 7, Issue 1, January 2019, Page: 35-41
Survival and Mortality of Patients with Hyponatremia in Intensive Care Units: A Retrospective Study of 327 Patients Hospitalized at Sylvanus Olympio University Hospital
Eyram Yoan Makafui Amekoudi, Department of Nephrology and Hemodialysis, University of Lome, Lome, Togo
Kossi Akomola Sabi, Department of Nephrology and Hemodialysis, University of Lome, Lome, Togo
Komlan Georges Tona, Department of Nephrology and Hemodialysis, University of Lome, Lome, Togo
Badomta Dolaama, Department of Nephrology and Hemodialysis, University of Lome, Lome, Togo
Béfa Noto-Kadou-Kaza, Department of Nephrology and Hemodialysis, University of Lome, Lome, Togo
Epiphane Kola, Department of Nephrology and Hemodialysis, University of Lome, Lome, Togo
Bayaki Saka, Department of Dermatology and Venerology, University of Lome, Lome, Togo
Received: Apr. 23, 2019;       Accepted: Jun. 10, 2019;       Published: Jun. 26, 2019
DOI: 10.11648/j.ajcem.20190701.15      View  33      Downloads  9
Abstract
Hyponatremia is recognized as the most common electrolyte disorder in hospitalization services. It is associated in the literature with a prolongation of the hospitalization with a variable mortality according to comorbidities and etiologies. In Togo, although empirically noted, this excess mortality has never been demonstrated. The objective of our study was to determine the survival and mortality of patients with hyponatremia in the intensive care units of the Sylvanus Olympio Hospital Center (CHU SO). We collected 2802 patients over the period from January 1, 2015 to December 31, 2016. Of these patients, 327 included patients, of whom 79 had hyponatremia, had a frequency of 23.6%. The prevalence of hyponatremia was 2.8%. The average of natremia was 126.3 ± 6.8 mmol/L with extremes of 100 mmol/L and 134 mmol/L. The mean age of patients was 52.3 ± 18.2 years (range: 18 to 92 years) with a sex ratio (M / F) of 1.5. The most common comorbidities were high blood pressure (32.9%) and diabetes (13.9%). The most common etiology was neurological (26.6%), renal (20.3%) and infectious (19%). The average duration of hospitalization was 11 days. The probability of survival after 11 days was 49%, with excess mortality depending on the severity of hyponatremia. Because of its importance hyponatremia appears as a cause of mortality. This study provides the prognosis of patients in intensive care and urges the implementation of ionogram monitoring technique.
Keywords
Hyponatremia, Epidemiology, Mortality, Survival, Sub-saharan Africa
To cite this article
Eyram Yoan Makafui Amekoudi, Kossi Akomola Sabi, Komlan Georges Tona, Badomta Dolaama, Béfa Noto-Kadou-Kaza, Epiphane Kola, Bayaki Saka, Survival and Mortality of Patients with Hyponatremia in Intensive Care Units: A Retrospective Study of 327 Patients Hospitalized at Sylvanus Olympio University Hospital, American Journal of Clinical and Experimental Medicine. Vol. 7, No. 1, 2019, pp. 35-41. doi: 10.11648/j.ajcem.20190701.15
Copyright
Copyright © 2019 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Reference
[1]
Quintard H, Facchini A, Gentelet C, Ichai C. Comment prendre en charge une dysnatrémie en neuroréanimation ? Prat En Anesth Réanimation. avr 2018; 22 (2): 105-9.
[2]
Roubille C, Jugant S, Jeantet G, Zerkowski L, Fesler P, Ribstein J. L’hyponatrémie, les examens paracliniques et l’interniste clinicien. Rev Médecine Interne. 2017; 38: A61.
[3]
Passeron A, Dupeux S, Blanchard A. Hyponatrémie: de la physiopathologie à la pratique. Rev Médecine Interne. 2010; 31 (4): 277–286.
[4]
Langlois PL, Bourguignon MJ, Manzanares W. L’hyponatrémie chez le patient cérébrolésé en soins intensifs: étiologie et prise en charge. Médecine Intensive Réanimation. 2016; 25 (5): 203–213.
[5]
Olsson K, Öhlin B, Melander O. Epidemiology and characteristics of hyponatremia in the emergency department. Eur J Intern Med. 1 mars 2013; 24 (2): 110-6.
[6]
Tamizifar B, Kheiry S, Fereidoony F. Hyponatremia and 30 days mortality of patients with acute pulmonary embolism. J Res Med Sci Off J Isfahan Univ Med Sci. août 2015; 20 (8): 777-81.
[7]
Bennani SL, Abouqal R, Zeggwagh AA, Madani N, Abidi K, Zekraoui A, et al. Incidence, causes and prognostic factors of hyponatremia in intensive care. Rev Med Interne. 2003; 24 (4): 224–229.
[8]
Hao J, Li Y, Zhang X, Pang C, Wang Y, Nigwekar SU, et al. The prevalence and mortality of hyponatremia is seriously underestimated in Chinese general medical patients: an observational retrospective study. BMC Nephrol. 31 oct 2017; 18 (1): 328.
[9]
Eckart A, Hausfater P, Amin D, Amin A, Haubitz S, Bernard M, et al. Hyponatremia and activation of vasopressin secretion are both independently associated with 30-day mortality: results of a multicenter, observational study. J Intern Med. 2018.
[10]
Traore F, Kouamé J, Ngoran K. Prévalence de l’hyponatrémie dans l’insuffisance cardiaque à l’institut de cardiologie. Abidjan. 2017; 22-30.
[11]
Kettaneh A, Mario N, Fardet L, Flick D, Fozing T, Tiev K, et al. Mortalité hospitalière et durée de séjour des patients non programmés en médecine interne: valeur pronostique de paramètres biochimiques usuels à l’admission. Rev Médecine Interne. juill 2007; 28 (7): 443-9.
[12]
Clayton JA, Le Jeune IR, Hall IP. Severe hyponatraemia in medical in-patients: aetiology, assessment and outcome. J Assoc Physicians. 2006; 99 (8): 505–511.
[13]
Creusot M-L, Clos Prophette F. Etude rétrospective des hyponatrémies hospitalisées dans un service de médecine polyvalente sur 13 mois. 2014;
[14]
Zieschang T, Wolf M, Vellappallil T, Uhlmann L, Oster P, Kopf D. The Association of Hyponatremia, Risk of Confusional State, and Mortality. Dtsch Arzteblatt Int. 16 déc 2016; 113 (50): 855-62.
[15]
Pokaharel M, Block CA. Dysnatremia in the ICU. Curr Opin Crit Care. déc 2011; 17 (6): 581-93.
[16]
Chalela R, González-García JG, Chillarón JJ, Valera-Hernández L, Montoya-Rangel C, Badenes D, et al. Impact of hyponatremia on mortality and morbidity in patients with COPD exacerbations. Respir Med. 2016; 117: 237-42.
[17]
Joosen D a. WA, Zwietering NA, Bosch M, Stassen PM. Characteristics and outcome of acute medical admissions with hyponatremia: even mild hyponatremia is associated with higher mortality. Acute Med. 2017; 16 (4): 156-63.
[18]
Yoshioka K, Matsue Y, Kagiyama N, Yoshida K, Kume T, Okura H, et al. Recovery from hyponatremia in acute phase is associated with better in-hospital mortality rate in acute heart failure syndrome. J Cardiol. mai 2016; 67 (5): 406-11.
Browse journals by subject