American Journal of Clinical and Experimental Medicine

Submit a Manuscript

Publishing with us to make your research visible to the widest possible audience.

Propose a Special Issue

Building a community of authors and readers to discuss the latest research and develop new ideas.

Research Article |

Correlation Between Serum 25-hydroxyvitamin D3 Levels and Children with Anxiety Disorder

Objective Explore the correlation between anxiety disorder and serum 25-hydroxyvitamin D3 (25-(OH) D3) level in children, in order to guide the diagnosis and treatment of childhood anxiety disorders and to supply clinical measure. Method The experimental group was 124 children with anxiety disorders attending the Child Behavior and Development Clinic of Jingzhou Maternal and Child Health Hospital from January 2020 to December 2022, as the control group was 131 children who had health checkups in the same hospital during the meantime. The differences of serum 25-(OH) D3 levels between the two groups were compared. Children with anxiety disorder were further divided into 4 age groups according to each group with 2 years (24 months) apart: 11-12 years old (32 cases), 13-14 years old (38 cases), 15-16 years old (31 cases) and larger than 16 years old (23 cases). Then, the difference of 25-hydroxyvitamin D among 16 years old group (23 cases) was compared. Results The serum 25-(OH) D3 level of the experimental group was distinctively lower than that of the control group, [(18.25±7.68) ng/ml VS (28.63±9.52) ng/ml], P<0.05, with statistical difference; The rate of vitamin D lack and insufficiency was higher than that of the control group (89.52% VS 75.57%), P<0.05, with statistical difference; According to age group grouping, the vitamin D levels in the 15-16 year old and>16 year old groups were lower than those in the 11-12 year old and 13-14 year old groups, with statistically significant differences (P<0.05). Conclusion: Vitamin D deficiency is more common in children with anxiety disorders, and is more pronounced in children older than 15 years than in younger children.

Anxiety Disorders, 25-hydroxyvitamin D3, Children

APA Style

Huang, W., Wang, Z. (2024). Correlation Between Serum 25-hydroxyvitamin D3 Levels and Children with Anxiety Disorder. American Journal of Clinical and Experimental Medicine, 12(1), 1-4. https://doi.org/10.11648/ajcem.20241201.11

ACS Style

Huang, W.; Wang, Z. Correlation Between Serum 25-hydroxyvitamin D3 Levels and Children with Anxiety Disorder. Am. J. Clin. Exp. Med. 2024, 12(1), 1-4. doi: 10.11648/ajcem.20241201.11

AMA Style

Huang W, Wang Z. Correlation Between Serum 25-hydroxyvitamin D3 Levels and Children with Anxiety Disorder. Am J Clin Exp Med. 2024;12(1):1-4. doi: 10.11648/ajcem.20241201.11

Copyright © 2024 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

1. Patel V, Saxena S, Lund C, et al. The Lancet Commission on global mental health and sustainable development [J]. Lancet, 2018, 392(10157): 1553-1598.
2. Christiane H, Mirjam F, Borge S, et al. Low 25(OH)-vitamin D concentrations are associated with emotional and behavioral problems in German children and adolescents [J]. PLOS one, 2017, 8: 1-16.
3. Mohammadi M, Ahmadi N, Yazdi P, et al. Prevalence, comorbidity and edictors of anxiety disorders among childrenand adolescents [J]. Asian J Psychiatr, 2020, 53: 102059.
4. Birmaher B, Khetarpal A, Brent D, et al. The Screen for Child Anxiety Related Emotional Disorders (SCARED): scale construction and psychometric characteristics [J]. J Am Acad ChildAdolesc Psychiatry, 1997, 36(4): 545-553.
5. Narrow W, Clarke D, Kuramoto SJ, et al. DSM-5 field trials in the United States and Canada, Part III: development and reliability testing of a cross-cutting symptom assessment for DSM-5 [J]. Am J Psychiatry, 2013, 170(1): 71-82.
6. Hanrahan F, Field APJones FW, et al. A meta-analysis of cognitive therapyfor worry in generalized anxiety disorder [J]. Clin Psychol Rev, 2013, 33(1): 120-132.
7. L ee J, Chi S, Lee MS. Molecular biomarkers for pediatric depressive disorders: a narrative review [J]. Int J Mol Sci, 2021, 22(18): 10051.
8. Zajkowska Z, Gullett N, Walsh A, et al. Cortisol and development of depression in adolescence and young adulthood: a systematic review and meta-analysis [J]. Psychoneuroendocrinology, 2022, 136: 105625.
9. Bouillon R. Vitamin D: From Photosynthesis, Metabolism and Action to Clinical Applications [M]. In: Endocrinology, Jameson JL, De Groot LJ (Eds), Saunders Elsevier, Philadelphia, 2020: 1018-1037.
10. Schmaal L, Hibar D, Sämann P, et al. Cortical abnormalities in adults and adolescents with major depression based on brain scans from 20 cohorts orldwide in the ENIGMA Major Depressive Disorder Working Group [J]. Mol Psychiatry, 2017, 22(6): 900-909.
11. Toenders YJ, van Velzen LS, Heideman IZ, et al. Neuroimaging predictors of onset and course of depression in childhood and adolescence: a systematic review of longitudinal studies [J]. Dev Cogn Neurosci, 2019, 39: 100700.
12. Milaneschi Y, Hoogendijk W, Lips P, et al. The association between low vitamin D and depressive disorders [J]. Mol Psychiatry, 2014; 19(4): 444–51.
13. Parker G, Brotchie H, Graham R. Vitamin D and depression [J]. J Affect Disord. 2016; 208: 56–61.
14. Eyles D, Burne T, McGrath J. Vitamin D, effects on brain development, adult brain function and the links between low levels of vitamin D and europsychiatric disease [J]. Front Neuroendocrinol. 2013; 34(1): 47–64.
15. Tolppanen A, Sayers A, Fraser W, et al. The association of serum 25-hydroxyvitamin D3 and D2 with depressive symptoms in childhood—a prospective cohort study [J]. Journal of child psychology and psychiatry, and allied disciplines. 2012; 53(7): 757–766.
16. Bener A, Khattab A, Al-Dabbagh M. Is high prevalence of Vitamin D deficiency evidence for autism disorder? In a highly endogamous population [J]. J Pediatr Neurosci. 2014; 9(3): 227–33.