Research Article
New Classification of Tumor Microvessels and the Risk of Regional Metastasis in Squamous Cell and Glandular Cancers
Marina Senchukova*
Issue:
Volume 12, Issue 5, October 2024
Pages:
61-73
Received:
22 October 2024
Accepted:
11 November 2024
Published:
29 November 2024
Abstract: Previously, we proposed a new classification of tumor microvessels (MVs) on the basis of their morphological features and clinical significance. The aim of this study was to summarize the obtained results and establish the predictive value of different types of tumor MVs for assessing the risk of metastasis to regional lymph nodes (RLNs) in glandular and squamous cell carcinomas. Materials and methods. A total of 385 archival samples of gastric cancer stages I--III, breast cancer stages I--IIIA, cervical squamous cell carcinoma stages I--IIA, and lung squamous cell carcinoma stages I--IIIA were studied. The tumor sections were processed routinely and subjected to immunohistochemistry with antibodies against cluster of differentiation 34 (CD34) and podoplanin. To assess independent predictors of the risk of metastasis to RLNs, correlation analysis and univariate and multivariate logistic regression analyses were performed. Statistical analysis was performed via Statistica 10.0 software. Results. For patients with gastric cancer and breast cancer, the independent predictors of a high risk of metastasis to RLNs are T2 (p=0.007) and T3 (p<0.00001) stages, tumor grade 3 (p=0.0002), the presence of lymphovascular invasion (LVI) (p=0.044) and peritumoral retraction clefts (p=0.008). For patients with squamous cell carcinoma of the cervix and lung, independent predictors of a high risk of metastasis to RLNs are the T2 (p=0.01) and T3 (p=0.007) stages, the presence of LVI (p=0.0014), dilated capillaries (DCs) of the "contact type" (p=0.0007), capillaries in the tumor solid component (p=0.046) and peritumoral retraction cleftings (p=0.0006). Conclusion. The results of the present study indicate that when assessing the risk of metastasis to RLNs, it is advisable to consider the presence of peritumoral retraction clefting and LVI in both glandular and squamous cell carcinomas. In addition, in squamous cell carcinomas, the accuracy of assessing the risk of metastasis to RLNs can be increased by taking into account "contact-type" DCs and capillaries in the solid component of the tumor.
Abstract: Previously, we proposed a new classification of tumor microvessels (MVs) on the basis of their morphological features and clinical significance. The aim of this study was to summarize the obtained results and establish the predictive value of different types of tumor MVs for assessing the risk of metastasis to regional lymph nodes (RLNs) in glandul...
Show More
Research Article
Efficacy and Determinant Factors of Linezolid Containing Regimens in the Treatment of DR - TB Patients at Saint Peter Specialized Hospital, Addis Ababa, Ethiopia, 2023 A Retrospective Study
Abdurehman Seid Mohammed*,
Mustofa Hassen Yesuf,
Chekole Sileshi Menbere,
Getachew Mekete Diress
Issue:
Volume 12, Issue 5, October 2024
Pages:
74-86
Received:
10 November 2024
Accepted:
23 November 2024
Published:
12 December 2024
Abstract: Background: A synthetic oxazolidinone antimicrobial medication called Linezolid is used to treat patients who are resistant to multiple drugs. Few studies have been done regarding the effectiveness of Linezolid-containing regimens in both developing and developed nations. This study aimed to determine the Efficacy and determinant factors of linezolid-containing regimens in the treatment of DR - TB Patients. Methods: An institution-based cross-sectional study design was conducted using SPSS version 26, and multivariable binary logistic regression analysis was used. Result: out of 345 patients that visited the outpatient clinic, 205 (59.4%) were males, and 126(36.5%) were between 30-39 years. MDR TB Patients' linezolid-containing regimen treatment efficacy success rate is 280(81.2%). MDR TB Patient Previously Treated TB by First Line Drug [AOR= 5.823(3.761-7.341)]. MDR TB Patient Previously Treated TB by First Line and treatment completed [AOR=2.351(1.34-3.214))], the adverse effect [AOR 0.842(0.674-2.431], tolerability of linezolid [AOR =2.543(2.41-4.532)] was significantly associated with linezolid containing regimen treatment efficacy rate. Conclusion: Linezolid-containing regimens have good efficacy and good treatment outcomes for DR-TB patients. The findings showed that Linezolid is a good choice for treating DR-TB, although patients ought to be monitored closely for the incidence of adverse effects.
Abstract: Background: A synthetic oxazolidinone antimicrobial medication called Linezolid is used to treat patients who are resistant to multiple drugs. Few studies have been done regarding the effectiveness of Linezolid-containing regimens in both developing and developed nations. This study aimed to determine the Efficacy and determinant factors of linezol...
Show More
