Research Article
Clinicopathological Characteristics of 11 Cases with Spiradenoma: A Rare Adnexal Tumor
Issue:
Volume 12, Issue 2, April 2024
Pages:
8-12
Received:
15 March 2024
Accepted:
29 March 2024
Published:
11 April 2024
Abstract: Objective: To explore the clinicopathological characteristics of spiradenoma (SA), and make exact diagnosis and differential diagnosis of this disease. Methods: The clinical and pathological data of 11 patients with spiradenoma in the First Affiliated Hospital of Jinan University from 2013 to 2022 were retrospectively analyzed, and combined with the review of literatures. Results: Among the 11 patients with spiroadenomas, 6 cases were male and 5 were female; the age ranged from 19 to 70 years old, with an average age of 41 years; Spiradenomas are more common in the trunk and limbs. At low-power microscope, the tumor mass with capsule in the dermis. Under a high-power microscope, the tumor is usually composed of two types of cells, which are the marginal small basaloid cells with dark staining and central larger cells with a pale and acidophilic nucleus. Other morphological structures included 2 cases of cystic solid and cylindroma respectively. Immunohistochemistry showed that epithelial and myoepithelial differentiation. Conclusion: Spiradenoma often occurs subcutaneously and requires histopathological diagnosis to avoid misdiagnosis. Its biological behavior is benign and its prognosis is good. But malignant transformation should be considered in some case with long course or relapses. SA is rare in clinical and is prone to misdiagnosis or missed diagnosis. This study summarizes the clinilcopathological characteristics of SA, providing reference for future clinical diagnosis and treatment.
Abstract: Objective: To explore the clinicopathological characteristics of spiradenoma (SA), and make exact diagnosis and differential diagnosis of this disease. Methods: The clinical and pathological data of 11 patients with spiradenoma in the First Affiliated Hospital of Jinan University from 2013 to 2022 were retrospectively analyzed, and combined with th...
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Research Article
An Overview of Emerging Trends in Gene Therapy for Cancer Treatment
Muhammad Haider Amin*
Issue:
Volume 12, Issue 2, April 2024
Pages:
13-19
Received:
26 March 2024
Accepted:
9 May 2024
Published:
24 May 2024
Abstract: Clinical trials have long recognized cancer treatment as a top priority. Different approaches have been devised for dealing with tumors of different types and at different stages. When it came to curing cancer, gene therapy was vital. The advancement of genome engineering technologies over the past thirty years has pushed forward gene therapy for the treatment and management of chronic diseases. It is the hope of researchers that one day they will be able to treat individuals with single gene disorders and complicated acquired diseases in a way that is both safe and successful. Gene delivery is a promising new method for detecting, diagnosing, and maybe treating cancer, made possible by recent developments in genetic engineering. Naked nucleic acid-based treatment, targeting microRNAs, oncolytic viral therapy, suicide gene-based therapy, targeting telomerase, cell-mediated gene therapeutics, and CRISPR/Cas9-based therapies are just few of the cancer medicines that have been created and tested in vitro and in vivo. This article provides a critical overview of the present and diverse cancer gene therapy methodologies, as well as a summary of the available viral and non-viral gene delivery mechanisms for gene therapy. In the future, biosafe carriers for gene products will play a crucial role in the prevention of cancer.
Abstract: Clinical trials have long recognized cancer treatment as a top priority. Different approaches have been devised for dealing with tumors of different types and at different stages. When it came to curing cancer, gene therapy was vital. The advancement of genome engineering technologies over the past thirty years has pushed forward gene therapy for t...
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