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Papillary Tumor of the Pineal Region: A Case Report and Literature Review
Peng Lilin,
Zhong Lijuan,
Yang Bo,
Lu Yuanzhi
Issue:
Volume 11, Issue 2, March 2023
Pages:
29-32
Received:
7 February 2023
Accepted:
1 March 2023
Published:
20 March 2023
Abstract: Pineal tumors of the pineal region (PTPR) are rare neuroepithelial tumors of the central nervous system, and their clinical features often lack specificity, so it is always difficult to make a definite diagnosis before surgery, and the treatment is mainly based on complete surgical resection. We report the case of a 21-year-old male who presented with intermittent dizziness and headache with vomiting for more than 2 months. The imaging revealed a mass in the region of the pineal region with obstructive hydrocephalus. After the hospitalization, the patient underwent a microscopic excision of the pineal mass, and the tissue was sent for histopathological examination and available immunohistochemical tests, which resulted in a definitive diagnosis of a papillary tumor of the pineal region. He had undergone several radiation treatments during his hospitalization and remained recurrence-free until the latest follow-up visit. This article highlights the similarities between this case and the PTPR described in WHO 2021 in terms of clinical presentation, imaging, and histopathological features. Therefore, this case report completes the sample database of PTPRs. By reviewing the literature related to PTPRs, we hope that this report will be helpful to improve the understanding of clinicians and pathologists about this rare tumor. However, more relevant studies are needed to clarify the pathogenesis, prognosis, and optimal treatment options to achieve early diagnosis, early treatment, and improved prognosis.
Abstract: Pineal tumors of the pineal region (PTPR) are rare neuroepithelial tumors of the central nervous system, and their clinical features often lack specificity, so it is always difficult to make a definite diagnosis before surgery, and the treatment is mainly based on complete surgical resection. We report the case of a 21-year-old male who presented w...
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Performance Evaluation of Machine Learning Methods for Heart Failure Prediction
Issue:
Volume 11, Issue 2, March 2023
Pages:
33-38
Received:
21 February 2023
Accepted:
22 March 2023
Published:
31 March 2023
Abstract: Heart failure is a syndrome of cardiac circulation disorder. Due to the dysfunction of the systolic function or diastolic function of the heart, the venous blood volume cannot be fully discharged from the heart, resulting in blood stasis in the venous system and insufficient perfusion in the arterial system. The symptoms of this disorder are concentrated in pulmonary congestion and vena cava congestion. The correlation between the inducement of heart failure and the incidence of heart failure is a subject that needs to be studied in the medical field. In recent years, with the development of data mining technology, more and more analytical models and algorithms have been applied in the medical field, which greatly improve the efficiency of medical data analysis and enable medical workers to cure diseases better. In this study, an ensemble learning model is applied to analyze the data of heart failure. First, the data is preprocessed and normalized, and features that are not associated with death rate of heart failure are removed. Secondly, multiple base classifiers are trained and compared. Finally, the competent base classifiers are selected and integrated with the Stacking-based ensemble learning algorithm for final classification. Comparative analysis showed that the prediction results of ensemble model are better than that of base classifiers in evaluation indexes such as accuracy, precision, AUC, Balanced accuracy and F1-score for the heart failure data.
Abstract: Heart failure is a syndrome of cardiac circulation disorder. Due to the dysfunction of the systolic function or diastolic function of the heart, the venous blood volume cannot be fully discharged from the heart, resulting in blood stasis in the venous system and insufficient perfusion in the arterial system. The symptoms of this disorder are concen...
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Research Progress of Serum VEGF and FAS in Prognosis of Gastric Cancer
Hou Jianzhang,
Zhang Shuli,
Yuan Jianlei,
Li Hongyan,
Hou Zhenjiang
Issue:
Volume 11, Issue 2, March 2023
Pages:
39-46
Received:
14 March 2023
Accepted:
18 April 2023
Published:
20 April 2023
Abstract: Vascular endothelial growth factor (VEGF) is an important factor to promote endothelial cell division and angiogenesis. In physiological conditions, the expression level of VEGF in human tissues is very low. Ischemia, hypoxia and many tumors can promote the synthesis and secretion of VEGF, and its expression level is related to the degree of vascularization of tumors, the proliferation, growth and metastasis of tumor cells. Fatty acid synthase (FAS) is a key enzyme for endogenous fatty acid synthesis, which is expressed at a low level in normal tissue cells, while FASN in a variety of tumor cells is continuously highly expressed to meet the energy needs of cell proliferation and the excessive demand for rapid proliferation of tumor cells to form cell membrane lipids. A large amount of research shows that VEGF and FAS play an important role in the development and development of many tumors, and the abnormally high expression in tumor tissue cells is positively correlated with serum VEGF and FAS levels, which is closely related to the prognosis of tumors. Gastric cancer (GC) is one of the most common clinical malignant tumors of the digestive tract, and its incidence and mortality have shown an increasing trend in recent years, and the prognosis is poor, seriously endangering human health. The biological properties of GC are related to the level of VEGF and FAS expression in tissues and serum. This article reviews the research progress of VEGF and FAS, their expression in GC and their prognosis.
Abstract: Vascular endothelial growth factor (VEGF) is an important factor to promote endothelial cell division and angiogenesis. In physiological conditions, the expression level of VEGF in human tissues is very low. Ischemia, hypoxia and many tumors can promote the synthesis and secretion of VEGF, and its expression level is related to the degree of vascul...
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