-
Comparison of the Effectiveness of Tretinoin 0.05% Gel and Adapalene 0.1% Gel Based on Clinical Manifestations, and Sebum Levels in Mild Acne Vulgaris Patients
Asrawati Sofyan,
Farida Tabri,
Sri Vitayani Muchtar,
Idham Jayaganda,
Gemini Alam,
Safruddin Amin,
Anis Anwar Irawan
Issue:
Volume 4, Issue 5, September 2016
Pages:
118-121
Received:
7 June 2015
Accepted:
11 May 2016
Published:
3 August 2016
Abstract: This study aimed to compare the effectiveness of tretinoin 0.05% gel and adapalene 0.1% gel by observing any changes in clinical manifestations and sebum levels before, during and after treatment. This study was carried out in public hospitals and network hospitals in the city of Makassar with double-blind prospective cohort of pre and post treatment. The research sample were thirty-eight patients with mild acne vulgaris who have been observed for the change in the clinical manifestations, measured levels of sebum with sebumeter. The results showed no significant difference between the use of tretinoin 0.05% gel and adapalene 0.1% gel in patients with mild acne vulgaris. There were significant changes of clinical manifestations of two treatment on day 7 and day 14. Levels of sebum by the administration of adapalene 0.1% gel decreased significantly (p <0.05) at day 42, faster than the 0.05% tretinoin gel.
Abstract: This study aimed to compare the effectiveness of tretinoin 0.05% gel and adapalene 0.1% gel by observing any changes in clinical manifestations and sebum levels before, during and after treatment. This study was carried out in public hospitals and network hospitals in the city of Makassar with double-blind prospective cohort of pre and post treatme...
Show More
-
Expression of Patched-1 Protein in Aggressive and Nonaggressive Basal Cell Carcinoma
Putu Marcelina,
Alwi Mappiasse,
Anis Irawan Anwar,
Idham Jaya Ganda,
Mohammad Hatta,
Rina Masadah
Issue:
Volume 4, Issue 5, September 2016
Pages:
122-128
Received:
30 June 2016
Accepted:
30 July 2016
Published:
21 August 2016
Abstract: Basal cell carcinoma (BCC) or basalioma, is a skin cancer characterized by slow-growing, minimal local invasion, rarely metastasize, but can result in extensive morbidity through local invasion and tissue destruction if the treatment was delayed. In this genomic era, aggressiveness of BCC mainly affected by intrinsic factor such as molecular biological dysregulation. The aim of this study was to assess the correlation between level of PTCH1 protein expression and aggressiveness of BCC histopathology. This study was an observational and cross-sectional study with analytical approach, conducted at Outpatient Clinic of Dermatology and Venereology Department of Dr. Wahidin Sudirohusodo Hospital Makassar, Hasanuddin University Hospital, Anatomical Pathology Laboratory of Dr. Wahidin Sudirohusodo and Hasanuddin University Hospital, and Sentra Diagnostic Patologia Laboratory, Makassar from September 2014 to January 2016. Total sample was 37 paraffin block evaluated and classified as aggressive and nonaggressive BCC by histopathological finding. Aggressive type BCCs were 34 samples (91.9%) and nonaggressive type were 3 samples (8.1%). Micronodular type was the most common histopathologic feature in 30 of 37 subjects (81.1%) and 30 of 88 histopathological finding (34.1%). Each subject can have more than one histopathologic type. Percentage of strong expression PTCH1 was found highest in pigmented type (33.4%), the percentage of moderate expression PTCH1 was found highest in infiltrating type (60.0%), and the percentage of negative/weak PTCH1 expression was found highest in the nodular type (75.0%). In this study, the correlation between the aggressiveness and PTCH 1 expression was not significant statistically (p>0.05), but it is seen that the frequency of strong PTCH1 expression was found to be higher in aggressive than nonaggressive BCC.
Abstract: Basal cell carcinoma (BCC) or basalioma, is a skin cancer characterized by slow-growing, minimal local invasion, rarely metastasize, but can result in extensive morbidity through local invasion and tissue destruction if the treatment was delayed. In this genomic era, aggressiveness of BCC mainly affected by intrinsic factor such as molecular biolog...
Show More
-
Hair’s Zinc Level on Androgenic Alopecia
Nurul Rumila Roem,
Farida Tabri,
Nurelly N. Waspodo,
Ilhamjaya Patellongi,
Agussalim Bukhari,
Nursiah La Nafie
Issue:
Volume 4, Issue 5, September 2016
Pages:
129-133
Received:
19 July 2016
Accepted:
30 July 2016
Published:
25 August 2016
Abstract: Androgenic alopecia is characterized by progressive loss of hair from the scalp. This research aimed to determine the hair and blood zinc levels in men with androgenic alopecia. The research was conducted in the Departement of Dermatovenereology of Dr. Wahidin Sudirohusodo Hospital, Makassar and the Center for Health Laboratory, Makassar, using the observational research method. The samples comprised 21 males with androgenic alopecia and 11 control samples without androgenic alopecia. The hair and blood of the samples were analyzed using the atomic absorption spectrophotometer receipts. The results showed that there was significant difference (p <0.05) between the levels of androgenic alopecia hair zinc and control. On blood zinc levels found no significant differences between androgenic alopecia and control. Hair zinc levels had a significant relationship with the degree of Hamilton, where the lower the levels of zinc in the hair androgenic alopecia, the greater the degree of Hamilton. However, things are different, between blood zinc levels in hair zinc levels and degrees of Hamilton that there is no significant difference. In this study also found between age and degree of Hamilton, where the increasing age, the greater the degree of Hamilton.
Abstract: Androgenic alopecia is characterized by progressive loss of hair from the scalp. This research aimed to determine the hair and blood zinc levels in men with androgenic alopecia. The research was conducted in the Departement of Dermatovenereology of Dr. Wahidin Sudirohusodo Hospital, Makassar and the Center for Health Laboratory, Makassar, using the...
Show More
-
Comparison of Human Menopousal Gonadotropin with Recombinant Follicle Stimulating Hormone in Ovulation Stimulation During Intrauterine Insemination
Issue:
Volume 4, Issue 5, September 2016
Pages:
134-137
Received:
13 August 2016
Accepted:
1 September 2016
Published:
21 September 2016
Abstract: Fecundability increases when ovulation induction was conducted before starting intrauterine insemination procedure (IUI). Human Menopousal gonadotrophin (HMG) and recombinant follicle stimulating hormone (rFSH) are gonadotropin hormones that are widely used in the stimulation of ovulation in infertile patients. Although comparison of gonadotropin preparations have been carried out in IVF, but comparison of rFSH preparations and HMG on IUI was still lacking. The aim of this study was to compare rFSH and HMG, each was combined with clomiphene citrate in infertile women undergone intrauterine insemination (IUI). This study was a retrospective study in the Department of Obstetrics and Gynecology Wahidin Sudirohusodo. Samples were infertile patients who meet these following criteria: women aged 20-45 years, infertility of unknown cause for approximately 12 months, had a history of induced ovulation for approximately 6 cycles without IUI, IVF or ICSI, patent tubes examined with hysterosalpingography, and normal semen analysis according to 1999 WHO criteria. A total of 78 patients consisted of 30 patients using clomiphene citrate + rFSH and 48 other patients using clomiphene citrate + HMG. In two groups, total dosage, duration of gonadotropin administration, follicle count, mean size of follicles, endometrial line size and pregnancy were compared. Statistical test using Levene T and unpaired t test was conducted using SPSS 16 for Windows version. There was no statistically significant difference among total dosage, duration of gonadotropins administration, follicle counts, mean size of follicles, and endometrial line size. The mean number of pregnancy was higher in patients treated with clomiphene citrate + hMG but this difference was not statistically significant. hMG and rFSH was equally effective in stimulating ovulation in intrauterine insemination.
Abstract: Fecundability increases when ovulation induction was conducted before starting intrauterine insemination procedure (IUI). Human Menopousal gonadotrophin (HMG) and recombinant follicle stimulating hormone (rFSH) are gonadotropin hormones that are widely used in the stimulation of ovulation in infertile patients. Although comparison of gonadotropin p...
Show More
-
The Correlation Between the Anxiety and the Amount of the Sweat Gland Secretion in the Patients with Palmar Hyperhidrosis
Regina Mihardja,
Alwi Mappiasse,
Anis Irawan Anwar,
Arifin Seweng,
Sonny Lisal,
Andi Wardihan Sinrang
Issue:
Volume 4, Issue 5, September 2016
Pages:
138-145
Received:
21 July 2016
Accepted:
31 August 2016
Published:
29 September 2016
Abstract: Hyperhidrosis is also known as polyhidrosis or sudorrhea, which defines as the secretion of the sweat that exceeds the amount necessary for thermoregulation of the body. Palmar hyperhidrosis is excessive sweat secretion and is limited to the area of the palm. Anxiety is associated with feelings of uncertainty and helplessness. This emotional state does not have a specific object. Conditions subjectively experienced and communicated in interpersonal relationships. The purpose of this study was to determine the relationship between anxiety with the number of sweat glands secretion in patients with palmar hyperhidrosis. This study was an observational study with cross sectional design and analytical approach, conducted at Outpatient Clinic of Dermatology and Venereology Department of Dr. Wahidin Sudirohusodo Makassar, Hasanuddin University Hospital, and Senior High School in Makassar. This study began in February to April 2016. The number of samples are 40 people who suffered from palmar hyperhidrosis with the largest age distribution that is less than 20 years as many as 26 samples (65.0%). A total of 40 samples (100.0%) do not suffer secondary disorder, experiencing excessive sweating for at least 6 months, lasting at least one week, with bilateral symmetrical distribution, the onset of age 25 or younger and no sweat at night day. Family history of suffering from palmar hyperhidrosis were found in 12 samples (30.0%). There is a daily impact on palmar hyperhidrosis patients as many as 13 samples (32.5%). Students are the most in this study as many as 26 samples (65.0%). The onset of age palmar hyperhidrosis is the most at the age of 13 to 18 years from 21 samples (52.2). The severe palmar hyperhidrosis is the most in this study, there are 16 samples (40.0%). The degrees of moderate anxiety were the most in this study as many as 25 samples (62.5%). In this study, there is a tendency relationship between the degree of anxiety by the number of sweat glands secretion. Norepinephrine associated with severity of palmar hyperhidrosis. The highest level of norepinephrine is in the mild grade of palmar hyperhidrosis. There is a tendency correlation between the score of the Hamilton Rating Scale for Anxiety with blood plasma norepinephrine levels.
Abstract: Hyperhidrosis is also known as polyhidrosis or sudorrhea, which defines as the secretion of the sweat that exceeds the amount necessary for thermoregulation of the body. Palmar hyperhidrosis is excessive sweat secretion and is limited to the area of the palm. Anxiety is associated with feelings of uncertainty and helplessness. This emotional state ...
Show More
-
Effect of Amlodipine Alone and in Combination with Enalapril on Lipid Profile in Hypertensive Patients with Chronic Kidney Disease (Gaza Strip)
Hidaya Sobhi Saker,
Amin Tawfeeq Hamed,
Amal Fares Jamee,
Mahmoud Jalal Wadi
Issue:
Volume 4, Issue 5, September 2016
Pages:
146-150
Received:
23 August 2016
Accepted:
3 September 2016
Published:
11 October 2016
Abstract: Hypertension with dyslipidemia is becoming a common morbidity and hyperlipidemia is considered as an independent risk factor in development of cardiovascular diseases [1]. To evaluate the effects of Amlodipine (Calcium channel blocker) alone and in combination with Enalapril (Angiotensin Converting Enzyme inhibitor) on serum lipid profile in hypertensive patients with Chronic Kidney Disease (CKD), fifty hypertensive patients with CKD were divided equally into Amlodipine (5-10mg/day) treated group and Amlodipine/Enalapril combination (5-10mg/day, 10-20mg/day) treated group. Serum lipid profile were determined before and after 2, 4 and 6 months of treatment in both groups. A significant decrease in the levels of serum lipid profile in the hypertensive patients with CKD resulted with Amlodipine therapy alone and in combination with Enalapril. In both treated groups, the used drugs significantly improved Total cholesterol (TC), Triglycerides (TG), High Density Lipoprotein Cholesterol (HDL-C) and Low Density Lipoprotein Cholesterol (LDL-C) levels of the patients. The effect on these parameters being more pronounced in the group treated with the combination drug, when compared to that of Amlodipine treatment alone. The results indicated that both, Amlodipine monotherapy as well as Amlodipine/Enalapril combination affect the lipid profile. The observed overall higher protective effect of the combination as compared to that of Amlodipine monotherapy may improve the cardiovascular changes caused by hypertensive nephropathy.
Abstract: Hypertension with dyslipidemia is becoming a common morbidity and hyperlipidemia is considered as an independent risk factor in development of cardiovascular diseases [1]. To evaluate the effects of Amlodipine (Calcium channel blocker) alone and in combination with Enalapril (Angiotensin Converting Enzyme inhibitor) on serum lipid profile in hypert...
Show More
-
Assessment of Growing Pain and Its Risk Factors in School Children
Mujammel Haque,
Kamrul Laila,
Mohammed Mahbubul Islam,
Mohammad Imnul Islam,
Manik Kumar Talukder,
Shahana Akhter Rahman
Issue:
Volume 4, Issue 5, September 2016
Pages:
151-155
Received:
31 August 2016
Accepted:
14 September 2016
Published:
17 October 2016
Abstract: Background: Limb pain in children is a major diagnostic challenge. In majority of cases limb pain are due to growing pain (GP), which is the most common form of episodic childhood musculoskeletal pain. Some standard criteria are being used for diagnosis of GP. Objective: This study was undertaken to identify the frequency of growing pain and to determine its presentation and risk factors in school children. Methodology: This cross sectional study was conducted from January 2014 to December 2014 among school children aged 6-12 years in four Kindergarten schools at Bhairab Thana in Kishoregonj District. Standard criteria given by Peterson (1986) were used in this study for diagnosis of GP. Pretested questionnaires in Bangla were distributed among the children of Class One to Class Five by purposive sampling. After completions by parents or caregiver, questionnaires were collected from the schools and children with limb pain were selected for further history and clinical examination. Age and sex matched healthy children were selected as controls for comparison of risk factors. Results: Among 540 distributed questionnaires 404 (74.8%) responded. Among responders 95 (23.5%) had limb pain of which 78 (19.3%) were diagnosed as GP (40 were male and 38 were female). Highest number of cases was found in 8+ year age group. Site of pain was calf muscle (69.2%) in the majority. Timing of pain was at night in 82.05% cases. In 66.6% of cases pain was improved with massage. GP hampered activities like sleep in 26.9%, sports in 21.7% and schooling in 8.9%. GP was associated with headache in 12.8% and abdominal pain in 6.4% cases. Obesity, overweight, over activity and family history of GP were found significantly higher among GP cases than controls. Conclusion: Growing pain was found to be the most common cause of limb pain. Typical presentation of GP and multiple risk factors like obesity, over activity and family history were identified in this study.
Abstract: Background: Limb pain in children is a major diagnostic challenge. In majority of cases limb pain are due to growing pain (GP), which is the most common form of episodic childhood musculoskeletal pain. Some standard criteria are being used for diagnosis of GP. Objective: This study was undertaken to identify the frequency of growing pain and to det...
Show More
-
The Trend Towards the Right (Proximal) Shift of Colorectal Cancer: Is Not Observed in Sudanese Patients
Hyder Osman Mirghani,
Ali Adam Elhadi,
Ibrahim Abdullah Albalawi
Issue:
Volume 4, Issue 5, September 2016
Pages:
156-159
Received:
6 September 2016
Accepted:
21 September 2016
Published:
18 October 2016
Abstract: Background: There is a tendency of colorectal cancer towards a right shift, and increasing incidence among the young age groups. In this study, we aimed to assess the pattern of colorectal cancer among Sudanese patients attending an endoscopy unit in Omdurman Teaching Hospital. Subjects and Methods: This descriptive cross- sectional study conducted among thirty patients referred with the provisional diagnosis of colorectal cancer during the period from August 2015 to June 2016. Participants signed a written informed consent then interviewed to collect demographic data, symptoms related to carcinoma of the colon, the patients were then examined for evidence of anemia, intestinal obstruction, and ascites, colonoscopy with biopsy for histopathology was done. The ethical committee of the Omdurman Teaching Hospital approved the research, and the Statistical Package for Social Sciences (SPSS) was used for data analysis. Results; Out of thirty patients with the diagnosis of colorectal cancer, their ages ranged from 18-76 years with a mean of 51.1. The commonest presentations were rectal bleeding, change in the bowel habits, and constipation in 90%, 80%, and 60% respectively. Fourteen (46.7% were ≤ 50 years. The family history of colorectal cancer was evident in 16.7%, the recto-sigmoid area was the commonest site (83.3%), with 100% adenocarcinoma. Conclusion: Colorectal cancer tend to affect the younger age groups, the majority were recto-sigmoid (the proximal shift was not observed). The adenocarcinoma was the commonest histopathology.
Abstract: Background: There is a tendency of colorectal cancer towards a right shift, and increasing incidence among the young age groups. In this study, we aimed to assess the pattern of colorectal cancer among Sudanese patients attending an endoscopy unit in Omdurman Teaching Hospital. Subjects and Methods: This descriptive cross- sectional study conducted...
Show More
